Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-strand breaks has not been examined in in vivo system. Here we utilize non-homologous end joining (NHEJ) reporter mice to show that short-term CR strongly enhances DNA repair by NHEJ, which is associated with elevated levels of DNA-PK and SIRT6.
Calorie restriction (CR) without malnutrition slows the biological aging process and results in lifespan extension in a number of species1. In mice, CR by reduction in calorie intake by 30–40% extends both mean and maximum lifespan by 30–40%2,3. CR provides many beneficial health effects, including: reduced incidence of tumors, obesity, diabetes, autoimmune diseases, sarcopenia, and cardiovascular diseases.
SOURCES- Aging and Mechanism of Disease -Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
Written By Brian Wang, Nextbigfuture.com